Dataset Information

The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis.

ABSTRACT:

Objectives

Lean mass is commonly measured by 3 modalities, dual energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and computerized tomography (CT). CT is considered the most accurate, while lean mass measured by DXA and BIA often consists of non-muscle compartment, and hence considered less accurate when compared with CT. It remains unclear if the association of lean mass with mortality would differ using different measurement modalities.

Methods

A systematic review and meta-analysis of lean mass and mortality was conducted. The analysis was stratified by different measurement modalities and health conditions. Pooled hazard ratios were estimated using a random effects model.

Results

This meta-analysis included 188 studies with 98 468 participants. Reduced lean mass measured by BIA, DXA, and CT, was associated with increased risk of mortality with a hazard ratio (HR) of 1.35 (95% CI, 1.21-1.49), 1.18 (95% CI, 1.06-1.30), and 1.44 (95% CI, 1.32-1.57), respectively. Similarly, low lean mass defined by BIA-, DXA-, and CT-measurement was associated with increased risk of mortality, with an HR of 1.81 (95% CI, 1.56-2.10), 1.44 (95% CI, 1.29-1.60), and 1.78 (95% CI, 1.64-1.93).

Conclusions

Reduced and low lean mass were robustly associated with increased mortality in studies using different measurement modalities.

SUBMITTER: Li GH

PROVIDER: S-EPMC8088995 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis.

Li Gloria Hoi-Yee GH Lee Grace Koon-Yee GK Au Philip Chun-Ming PC Chan Marcus M Li Hang-Long HL Cheung Bernard Man-Yung BM Wong Ian Chi-Kei IC Lee Victor Ho-Fun VH Mok James J Yip Benjamin Hon-Kei BH Cheng Kenneth King-Yip KK Wu Chih-Hsing CH Cheung Ching-Lung CL

Osteoporosis and sarcopenia 20210312 Suppl 1

<h4>Objectives</h4>Lean mass is commonly measured by 3 modalities, dual energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and computerized tomography (CT). CT is considered the most accurate, while lean mass measured by DXA and BIA often consists of non-muscle compartment, and hence considered less accurate when compared with CT. It remains unclear if the association of lean mass with mortality would differ using different measurement modalities.<h4>Methods</h4>A systema ...[more]

PMID: 33997304

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Dataset Information

The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis.

Objectives

Methods

Results

Conclusions

Publications

The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis.

Similar Datasets

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