Longitudinal Evaluation of Cerebral Growth Across Childhood in Boys and Girls With Autism Spectrum Disorder.

ABSTRACT:

Background

Cerebral overgrowth is frequently reported in children but not in adults with autism spectrum disorder (ASD). This suggests that early cerebral overgrowth is followed by normalization of cerebral volumes. However, this notion is predicated on cross-sectional research that is vulnerable to sampling bias. For example, autistic individuals with disproportionate megalencephaly, a subgroup with higher rates of intellectual disability and larger cerebral volumes, may be underrepresented in studies of adolescents and adults. Furthermore, extant studies have cohorts that are predominately male, thus limiting knowledge of cerebral growth in females with ASD.

Methods

Growth of total cerebral volume, gray matter (GM) volume, and white matter volume as well as proportion of G

SUBMITTER: Lee JK 

PROVIDER: S-EPMC8089123 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature