Ontology highlight
ABSTRACT:
SUBMITTER: Nishimoto R
PROVIDER: S-EPMC8092382 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Nishimoto Rei R Derouiche Sandra S Eto Kei K Deveci Aykut A Kashio Makiko M Kimori Yoshitaka Y Matsuoka Yoshikazu Y Morimatsu Hiroshi H Nabekura Junichi J Tominaga Makoto M
Proceedings of the National Academy of Sciences of the United States of America 20210401 17
Microglia maintain central nervous system homeostasis by monitoring changes in their environment (resting state) and by taking protective actions to equilibrate such changes (activated state). These surveillance and protective roles both require constant movement of microglia. Interestingly, induced hypothermia can reduce microglia migration caused by ischemia, suggesting that microglia movement can be modulated by temperature. Although several ion channels and transporters are known to support ...[more]