A 2-pyridone amide inhibitor of transcriptional activity in Chlamydia trachomatis.

ABSTRACT: Chlamydia trachomatis is a strict intracellular bacterium that causes sexually transmitted infections and eye infections that can lead to life-long sequelae. Treatment options are limited to broad-spectrum antibiotics that disturb the commensal flora and contribute to selection of antibiotic-resistant bacteria. Hence, development of novel drugs that specifically target C. trachomatis would be beneficial. 2-pyridone amides are potent and specific inhibitors of Chlamydia infectivity. The first generation compound KSK120, inhibits the developmental cycle of Chlamydia resulting in reduced infectivity of progeny bacteria. Here, we show that the improved, highly potent second-generation 2-pyridone amide KSK213 allowed normal growth and development of C. trachomatis

SUBMITTER: Nunez-Otero C 

PROVIDER: S-EPMC8092867 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature