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Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans.

ABSTRACT: Motor inhibitory control implemented as response inhibition is an essential cognitive function required to dynamically adapt to rapidly changing environments. Despite over a decade of research on the neural mechanisms of response inhibition, it remains unclear, how exactly response inhibition is initiated and implemented. Using a multimodal MEG/fMRI approach in 59 subjects, our results reliably reveal that response inhibition is initiated by the right inferior frontal gyrus (rIFG) as a form of attention-independent top-down control that involves the modulation of beta-band activity. Furthermore, stopping performance was predicted by beta-band power, and beta-band connectivity was directed from rIFG to pre-supplementary motor area (pre-SMA), indicating rIFG's dominance over pre-SMA. Thus, these results strongly support the hypothesis that rIFG initiates stopping, implemented by beta-band oscillations with potential to open up new ways of spatially localized oscillation-based interventions.

SUBMITTER: Schaum M 

PROVIDER: S-EPMC8096430 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans.

Schaum Michael M   Pinzuti Edoardo E   Sebastian Alexandra A   Lieb Klaus K   Fries Pascal P   Mobascher Arian A   Jung Patrick P   Wibral Michael M   Tüscher Oliver O  

eLife 20210323

Motor inhibitory control implemented as response inhibition is an essential cognitive function required to dynamically adapt to rapidly changing environments. Despite over a decade of research on the neural mechanisms of response inhibition, it remains unclear, how exactly response inhibition is initiated and implemented. Using a multimodal MEG/fMRI approach in 59 subjects, our results reliably reveal that response inhibition is initiated by the right inferior frontal gyrus (rIFG) as a form of a  ...[more]

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