Comparative proteomics of Brucella melitensis is a useful toolbox for developing prophylactic interventions in a One-Health context.

ABSTRACT: Brucellosis caused by Brucella melitensis is a zoonosis frequently reported in the Mediterranean and Middle-East regions and responsible for important economic losses and reduced animal welfare. To date, current strategies applied to control or eradicate the disease relies on diagnostic tests that suffer from limited specificity in non-vaccinated animals; while prophylactic measures, when applied, use a live attenuated bacterial strain characterized by residual virulence on adult pregnant animals and difficulties in distinguishing vaccinated from infected animals. To overcome these issues, studies are desired to elucidate the bacterial biology and the pathogenetic mechanisms of both the vaccinal strain and the pathogenic strains. Proteomics has a potential in tackling issues of One-

SUBMITTER: Tilocca B 

PROVIDER: S-EPMC8100217 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature