Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis.

ABSTRACT:

Background

The parasite Taenia solium causes neurocysticercosis (NCC) in humans and is a common cause of adult-onset epilepsy in the developing world. Hippocampal atrophy, which occurs far from the cyst, is an emerging new complication of NCC. Evaluation of molecular pathways in brain regions close to and distant from the cyst could offer insight into this pathology.

Methods

Rats were inoculated intracranially with T. solium oncospheres. After 4 months, RNA was extracted from brain tissue samples in rats with NCC and uninfected controls, and cDNA was generated. Expression of 38 genes related to different molecular pathways involved in the inflammatory response and healing was assessed by RT-PCR array.

Results

Inflammatory cytokines IFN-γ, TNF-α, and IL-1, together wit

SUBMITTER: Carmen-Orozco RP 

PROVIDER: S-EPMC8104410 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature