Quantification of SV2A Binding in Rodent Brain Using [¹⁸F]SynVesT-1 and PET Imaging.

ABSTRACT:

Purpose

Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and neuropsychiatric disorders play a critical role in the drug discovery and development process, a robust, objective, and translational method for quantifying therapeutic drug efficacy in animal models will facilitate the drug development process. In this study, we tested the quantification reliability of the SV2A PET tracer, [¹⁸F]SynVesT-1, in a mouse model of AD (APP/PS1) and wild-type controls, and developed a simplified quantification method to facilitate

SUBMITTER: Sadasivam P 

PROVIDER: S-EPMC8105262 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature