Structure property relationships of N-acylsulfonamides and related bioisosteres.

ABSTRACT: The N-acylsulfonamide functional group is a feature of the pharmacophore of several biologically active molecules, including marketed drugs. Although this acidic moiety presents multiple points of attachments that could be exploited to introduce structural diversification, depending on the circumstances, the replacement of the functional group itself with a suitable surrogate, or bioisostere, may be desirable. A number of N-acylsulfonamide bioisosteres have been developed over the years that provide opportunities to modulate both structure and physicochemical properties of this important structural motif. To enable an assessment of the relative impact on physicochemical properties that these replacements may have compared to the N-acylsulfonamide group, we conducted a structure-property re

SUBMITTER: Francisco KR 

PROVIDER: S-EPMC8105289 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature