Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study.

ABSTRACT: When nanoparticles were introduced into the biological media, the protein corona would be formed, which endowed the nanoparticles with new bio-identities. Thus, controlling protein corona formation is critical to in vivo therapeutic effect. Controlling the particle size is the most feasible method during design, and the influence of media pH which varies with disease condition is quite important. The impact of particle size and pH on bovine serum albumin (BSA) corona formation of solid lipid nanoparticles (SLNs) was studied here. The BSA corona formation of SLNs with increasing particle size (120-480 nm) in pH 6.0 and 7.4 was investigated. Multiple techniques were employed for visualization study, conformational structure study and mechanism study, etc. "BSA corona-caused aggregatio

SUBMITTER: Wang W 

PROVIDER: S-EPMC8105779 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature