Endotyping chronic rhinosinusitis based on olfactory cleft mucus biomarkers.

ABSTRACT:

Background

Although chronic rhinosinusitis (CRS) is considered the most treatable form of olfactory dysfunction, there has been relatively little clinical attention focused on assessing endotypes as they pertain to olfactory loss.

Objectives

The goal of this study was to explore inflammatory endotypes in CRS using an unsupervised cluster analysis of olfactory cleft (OC) biomarkers in a phenotype-free approach.

Methods

Patients with CRS were prospectively recruited and psychophysical olfactory testing, Questionnaire of Olfactory Dysfunction (QOD-NS), and bilateral OC endoscopy were obtained. Mucus was collected from the OC and evaluated for 26 biomarkers using principal component analysis. Cluster analysis was performed using only OC biomarkers and differences in olfac

SUBMITTER: Soler ZM 

PROVIDER: S-EPMC8113080 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature