Ontology highlight
ABSTRACT:
SUBMITTER: Tesileanu CMS
PROVIDER: S-EPMC8113211 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Tesileanu C Mircea S CMS Vallentgoed Wies R WR Sanson Marc M Taal Walter W Clement Paul M PM Wick Wolfgang W Brandes Alba Ariela AA Baurain Jean Francais JF Chinot Olivier L OL Wheeler Helen H Gill Sanjeev S Griffin Matthew M Rogers Leland L Rudà Roberta R Weller Michael M McBain Catherine C Reijneveld Jaap J Enting Roelien H RH Caparrotti Francesca F Lesimple Thierry T Clenton Susan S Gijtenbeek Anja A Lim Elizabeth E de Vos Filip F Mulholland Paul J PJ Taphoorn Martin J B MJB de Heer Iris I Hoogstrate Youri Y de Wit Maurice M Boggiani Lorenzo L Venneker Sanne S Oosting Jan J Bovée Judith V M G JVMG Erridge Sara S Vogelbaum Michael A MA Nowak Anna K AK Mason Warren P WP Kros Johan M JM Wesseling Pieter P Aldape Ken K Jenkins Robert B RB Dubbink Hendrikus J HJ Baumert Brigitta B Golfinopoulos Vassilis V Gorlia Thierry T van den Bent Martin M French Pim J PJ
Acta neuropathologica 20210319 6
Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency in several tumour types. Even though these mutations are confined to distinct hotspots, we show that gliomas are the only tumour type with an exceptionally high percentage of IDH1<sup>R132H</sup> mutations. Patients harbouring IDH1<sup>R132H</sup> mutated tumours have lower levels of genome-wide DNA-methylation, and an associated increased gene expression, compared to tumours with other IDH1/2 mutations ...[more]