Single-cell multi-omics analysis of the immune response in COVID-19.

ABSTRACT: Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16⁺C1QA/B/C⁺) that sequester platelets and were predicted to replenish the alveolar macrophage pool in COVID-19. Early, uncommitted CD34⁺ hematopoietic stem/progenitor cells were primed toward megakaryopoiesis, accompanied by ex

SUBMITTER: Stephenson E 

PROVIDER: S-EPMC8121667 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature