Radiation- and Photo-Induced Oxidation Pathways of Methionine in Model Peptide Backbone under Anoxic Conditions.
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ABSTRACT:
SUBMITTER: Pedzinski T
PROVIDER: S-EPMC8125225 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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Radiation- and Photo-Induced Oxidation Pathways of Methionine in Model Peptide Backbone under Anoxic Conditions.
Pędzinski Tomasz T Grzyb Katarzyna K Skotnicki Konrad K Filipiak Piotr P Bobrowski Krzysztof K Chatgilialoglu Chryssostomos C Marciniak Bronislaw B
International journal of molecular sciences 20210430 9
Within the reactive oxygen species (ROS) generated by cellular metabolisms, hydroxyl radicals (HO<sup>•</sup>) play an important role, being the most aggressive towards biomolecules. The reactions of HO<sup>•</sup> with methionine residues (Met) in peptides and proteins have been intensively studied, but some fundamental aspects remain unsolved. In the present study we examined the biomimetic model made of Ac-Met-OMe, as the simplest model peptide backbone, and of HO<sup>•</sup> generated by ion ...[more]
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