Expression of CD40L on CD4⁺T cells distinguishes active versus inactive HIV-associated Kaposi's Sarcoma.

ABSTRACT: Kaposi's sarcoma (KS) is a malignancy of vascular origin. It is caused by the Kaposi's sarcoma-associated herpes virus (KSHV). Immune dysregulation is a key feature in the development and progression of KS. The main aim of this study was to determine and compare circulating CD4⁺ and CD8⁺T cell subsets including their expression of CD40 ligand (CD40L) and programmed cell death protein 1 (PD1), natural killer (NK) cells, and NK T cells between individuals with active HIV-associated KS versus those in remission. We found that the proportion of CD4⁺T cells was significantly higher in individuals in remission compared to those with active KS (26.3% vs 13.9%; p = 0.01). We also observed that the proportion of CD4⁺T cells and central memory CD4⁺

SUBMITTER: Ngalamika O 

PROVIDER: S-EPMC8127409 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature