Value of lipocalin 2 as a potential biomarker for bacterial meningitis.

ABSTRACT:

Objectives

Central nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly and accurately identify the likely cause of the infections, essential for clinical management and improving outcome.

Methods

We applied liquid chromatography tandem mass spectrometry on 45 cerebrospinal fluid (CSF) samples from a cohort of adults with and without CNS infections to discover potential diagnostic biomarkers. We then validated the diagnostic performance of a selected biomarker candidate in an independent cohort of 364 consecutively treated adults with CNS infections admitted to a referral hospital in Vietnam.

Results

In the discovery cohort, we identified lipocalin 2 (LCN2) as a potential bio

SUBMITTER: Thanh TT 

PROVIDER: S-EPMC8128987 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature