Mass Cytometry Identifies Expansion of T-bet⁺ B Cells and CD206⁺ Monocytes in Early Multiple Sclerosis.

ABSTRACT: Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous system. Immune cell features are particularly promising as predictive biomarkers due to their central role in the pathogenesis but also as drug targets, even if nowadays, they have no impact in clinical practice. Recently, high-resolution approaches, such as mass cytometry (CyTOF), helped to better understand the diversity and functions of the immune system. In this study, we performed an exploratory analysis of blood immune response profiles in healthy controls and MS patients sampled at their first neurological relapse, using two large CyTOF panels including 62 markers exploring myeloid and lymphoid cells. An increased abundance of both a T-bet-expressing B cell subset and a CD206⁺ classic

SUBMITTER: Couloume L 

PROVIDER: S-EPMC8129576 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature