Intravenous immunoglobulin treatment for patients with severe COVID-19: a retrospective multicentre study.

ABSTRACT:

Objectives

Intravenous immunoglobulin (IVIG) is commonly used to treat severe COVID-19, although the clinical outcome of such treatment remains unclear. This study evaluated the effectiveness of IVIG treatment in severe COVID-19 patients.

Methods

This retrospective multicentre study evaluated 28-day mortality in severe COVID-19 patients with or without IVIG treatment. Each patient treated with IVIG was matched with one untreated patient. Logistic regression and inverse probability weighting (IPW) were used to control confounding factors.

Results

The study included 850 patients (421 IVIG-treated patients and 429 non-IVIG-treated patients). After matching, 406 patients per group remained. No significant difference in 28-day mortality was observed after IPW analysis (ave

SUBMITTER: Liu J 

PROVIDER: S-EPMC8131555 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature