Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein.
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ABSTRACT:
SUBMITTER: Lapidus S
PROVIDER: S-EPMC8132281 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
<i>Plasmodium</i> infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein.
Lapidus Sarah S Liu Feimei F Casanovas-Massana Arnau A Dai Yile Y Huck John D JD Lucas Carolina C Klein Jon J Filler Renata B RB Strine Madison S MS Sy Mouhamad M Deme Awa B AB Badiane Aida S AS Dieye Baba B Ndiaye Ibrahima Mbaye IM Diedhiou Younous Y Mbaye Amadou Moctar AM Diagne Cheikh Tidiane CT Vigan-Womas Inés I Mbengue Alassane A Sadio Bacary D BD Diagne Moussa M MM Moore Adam J AJ Mangou Khadidiatou K Diallo Fatoumata F Sene Seynabou D SD Pouye Mariama N MN Faye Rokhaya R Diouf Babacar B Nery Nivison N Costa Federico F Reis Mitermayer M Muenker M Catherine MC Hodson Daniel Z DZ Mbarga Yannick Y Katz Ben Z BZ Andrews Jason R JR Campbell Melissa M Srivathsan Ariktha A Kamath Kathy K Baum-Jones Elisabeth E Faye Ousmane O Sall Amadou Alpha AA Quintero Vélez Juan Carlos JC Cappello Michael M Wilson Michael M Ben-Mamoun Choukri C Somé Fabrice A FA Dabiré Roch K RK Moukoko Carole Else Eboumbou CEE Ouédraogo Jean Bosco JB Boum Yap Y Shon John J Ndiaye Daouda D Wisnewski Adam A Parikh Sunil S Iwasaki Akiko A Wilen Craig B CB Ko Albert I AI Ring Aaron M AM Bei Amy K AK
medRxiv : the preprint server for health sciences 20210512
Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize <i>in vitro</i> SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population ...[more]
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