Ontology highlight
ABSTRACT:
SUBMITTER: Grivas D
PROVIDER: S-EPMC8138450 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Grivas Dimitrios D González-Rajal Álvaro Á de la Pompa José Luis JL
Frontiers in cell and developmental biology 20210507
Unlike the hearts of mammals, the adult zebrafish heart regenerates after injury. Heart cryoinjury in zebrafish triggers the formation of a fibrotic scar that gradually degrades, leading to regeneration. Midkine-a (Mdka) is a multifunctional cytokine that is activated after cardiac injury. Here, we investigated the role of <i>mdka</i> in zebrafish heart regeneration. We show that <i>mdka</i> expression was induced at 1-day post-cryoinjury (dpci) throughout the epicardial layer, whereas by 7 dpci ...[more]