Self-administration of adrenaline for anaphylaxis during in-hospital food challenges improves health-related quality of life.

ABSTRACT:

Objective

To assess the impact of anaphylaxis on health-related quality of life (HRQL) and self-efficacy in food-allergic patients undergoing in-hospital food challenge.

Design

Secondary analysis of a randomised controlled trial.

Setting

Specialist allergy centre.

Patients

Peanut-allergic young people aged 8-16 years.

Interventions

Double-blind, placebo-controlled food challenge to peanut, with HRQL and self-efficacy assessed using validated questionnaire, approximately 2 weeks prior to and 2 weeks after challenge. Where possible, anaphylaxis was treated with self-injected adrenaline (epinephrine).

Main outcome measures

Change in HRQL and self-efficacy.

Results

56 participants had reactions at food challenge, of whom 16 (29%) had anaphylaxi

SUBMITTER: Burrell S 

PROVIDER: S-EPMC8142442 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature