Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC8142859 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Liu Yafei Y Soh Wai Tuck WT Kishikawa Jun-Ichi JI Hirose Mika M Nakayama Emi E EE Li Songling S Sasai Miwa M Suzuki Tatsuya T Tada Asa A Arakawa Akemi A Matsuoka Sumiko S Akamatsu Kanako K Matsuda Makoto M Ono Chikako C Torii Shiho S Kishida Kazuki K Jin Hui H Nakai Wataru W Arase Noriko N Nakagawa Atsushi A Matsumoto Maki M Nakazaki Yukoh Y Shindo Yasuhiro Y Kohyama Masako M Tomii Keisuke K Ohmura Koichiro K Ohshima Shiro S Okamoto Toru T Yamamoto Masahiro M Nakagami Hironori H Matsuura Yoshiharu Y Nakagawa Atsushi A Kato Takayuki T Okada Masato M Standley Daron M DM Shioda Tatsuo T Arase Hisashi H
Cell 20210524 13
Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike protein domains are largely unknown. Here, we screened a series of anti-spike monoclonal antibodies from coronavirus disease 2019 (COVID-19) patients and found that some of antibodies against the N-terminal domain (NTD) induced the open conformation of RBD and thus enhanced the binding capacity of the spike protein to ACE2 and i ...[more]