ScDesign2: a transparent simulator that generates high-fidelity single-cell gene expression count data with gene correlations captured.
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ABSTRACT:
SUBMITTER: Sun T
PROVIDER: S-EPMC8147071 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
scDesign2: a transparent simulator that generates high-fidelity single-cell gene expression count data with gene correlations captured.
Sun Tianyi T Song Dongyuan D Li Wei Vivian WV Li Jingyi Jessica JJ
Genome biology 20210525 1
A pressing challenge in single-cell transcriptomics is to benchmark experimental protocols and computational methods. A solution is to use computational simulators, but existing simulators cannot simultaneously achieve three goals: preserving genes, capturing gene correlations, and generating any number of cells with varying sequencing depths. To fill this gap, we propose scDesign2, a transparent simulator that achieves all three goals and generates high-fidelity synthetic data for multiple sing ...[more]
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