Gene signatures of autopsy lungs from obese patients with COVID-19.

ABSTRACT:

Background & aims

Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19.

Methods

We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Patients were divided into 3 groups according to their comorbidities: hypertension, type 2 diabetes (T2D) and obesity. We then identified the molecular alterations associated with these comorbidities in COVID-19 patients.

Results

Patients with only hypertension showed higher levels of inflammatory genes and B-cell related genes when compared to those

SUBMITTER: Santos E Silva JC 

PROVIDER: S-EPMC8149170 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature