Identification of adipose tissue-related predictors of the reduction in cardiovascular risk induced by metabolic surgery.

ABSTRACT:

Objectives

We aimed to determine whether parameters associated with adipose tissue (adipocyte density and the circulating concentrations of markers of adipose tissue pathology) predict cardiovascular risk (CVR) modification after metabolic surgery (MS).

Methods

We performed a case-control study of patients with morbid obesity who were candidates for MS. CVR was defined using flow-mediated dilation (FMD) and carotid intima media thickness (CIMT), which were measured during the 9 months following MS. Subgroups of CVR reduction were defined using the following cut-offs: CIMT 10% and/or a two-fold increase in FMD.

Results

We studied 40 patients with morbid obesity (mean age 44.5 years, 75% women, mean body mass index 46.4 kg/m²) and high prevalences of the meta

SUBMITTER: Melchor-Lopez A 

PROVIDER: S-EPMC8150427 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature