Ontology highlight
ABSTRACT:
SUBMITTER: Brito A
PROVIDER: S-EPMC8152665 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Brito Alexandra A Pereira Patrícia M R PMR Soares da Costa Diana D Reis Rui L RL Ulijn Rein V RV Lewis Jason S JS Pires Ricardo A RA Pashkuleva Iva I
Chemical science 20200320 14
We report on aromatic <i>N</i>-glucosides that inhibit selectively the cancer metabolism <i>via</i> two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the cell surface through localized (biocatalytic) self-assembly. We demonstrate that the expression of the cancer associated GLUT1 and alkaline phosphatase are crucial for the effectiveness ...[more]