Signal transduction pathways involved in dopamine D₂ receptor-evoked emesis in the least shrew (Cryptotis parva).

ABSTRACT: With its five receptor subtypes (D_1-5), dopamine is implicated in a myriad of neurological illnesses. Dopamine D₂ receptor-based agonist therapy evokes nausea and vomiting. The signaling mechanisms by which dopamine D₂ receptors evoke vomiting remains unknown. Phosphatidylinositol 3-kinases (PI3K)- and protein kinase C (PKC)-related signaling cascades stimulate vomiting post-injection of various emetogens in emetically competent animals. This study investigated potential mechanisms involved in dopamine D₂ receptor-mediated vomiting using least shrews. We found that vomiting evoked by the selective dopamine D₂ receptor agonist quinpirole (2 mg/kg, i.p.) was significantly suppressed by: i) a dopamine D₂ p

SUBMITTER: Belkacemi L 

PROVIDER: S-EPMC8154667 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature