Ontology highlight
ABSTRACT:
SUBMITTER: Lee SR
PROVIDER: S-EPMC8157610 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Lee Sang R SR Lee Jong Geol JG Heo Jun H JH Jo Seong Lae SL Ryu Jihoon J Kim Globinna G Yon Jung-Min JM Lee Myeong Sup MS Lee Geun-Shik GS An Beum-Soo BS Shin Hyun-Jin HJ Woo Dong-Cheol DC Baek In-Jeoung IJ Hong Eui-Ju EJ
Cancers 20210518 10
Pgrmc1 is a non-canonical progesterone receptor related to the lethality of various types of cancer. PGRMC1 has been reported to exist in co-precipitated protein complexes with epidermal growth factor receptor (EGFR), which is considered a useful therapeutic target in hepatocellular carcinoma (HCC). Here, we investigated whether <i>Pgrmc1</i> is involved in HCC progression. In clinical datasets, <i>PGRMC1</i> transcription level was positively correlated with <i>EGFR</i> levels; importantly, <i> ...[more]