Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.

ABSTRACT: Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between kidney and muscle function remains poorly understood. Here, we took a complementary interorgan approach to investigate skeletal muscle wasting in CKD. We identified increased production and elevated blood levels of soluble pro-cachectic factors, including activin A, directly linking experimental and human CKD to skeletal muscle wasting programs. Single-cell sequencing data identified the expression of activin A in specific kidney cell populations of fibroblasts and cells of the juxtaglomerular apparatus. We propose that persistent and increased kidney production of pro-cachectic factors, combined with a lack of kidney clearance, facilit

SUBMITTER: Solagna F 

PROVIDER: S-EPMC8159690 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature