SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.

ABSTRACT: The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease outbreak, which can lead to acute respiratory distress syndrome (ARDS). However, it is still unclear how the virus interferes with immune cell and metabolic functions in the human body. In this study, we investigated the immune response in acute or convalescent COVID-19 patients. We characterized the peripheral blood mononuclear cells (PBMCs) using flow cytometry and found that CD8⁺ T cells were significantly subsided in moderate COVID-19 and convalescent patients. Furthermore, characterization of CD8⁺ T cells suggested that convalescent patients have significantly diminished expression of both perforin and granzyme A. Using ¹H-NMR spectroscopy, we characterized the metabo

SUBMITTER: Singh Y 

PROVIDER: S-EPMC8159709 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature