Surveillance of adverse drug events associated with tocilizumab in hospitalized veterans with coronavirus disease 2019 (COVID-19) to inform patient safety and pandemic preparedness.
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ABSTRACT:
SUBMITTER: Datta R
PROVIDER: S-EPMC8160489 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Surveillance of adverse drug events associated with tocilizumab in hospitalized veterans with coronavirus disease 2019 (COVID-19) to inform patient safety and pandemic preparedness.
Datta Rupak R Barrett Alexis A Burk Muriel M Salone Cedric C Au Anthony A Cunningham Francesca F Fisher Ann A Dembry Louise Marie LM Akgün Kathleen M KM
Infection control and hospital epidemiology 20210514 10
We evaluated adverse drug events (ADEs) by chart review in a random national sample of 428 veterans with coronavirus disease 2019 (COVID-19) who received tocilizumab (n = 173 of 428). ADEs (median time, 5 days) occurred in 51 of 173 (29%) and included hepatoxicity (n = 29) and infection (n = 13). Concomitant medication discontinuation occurred in 22% of ADE patients; mortality was 39%. ...[more]
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