Dual-Selective Catalysis in Dephosphorylation Tuned by Hf₆-Containing Metal-Organic Frameworks Mimicking Phosphatase.

ABSTRACT: Selective dephosphorylation is full of great challenges in the field of biomimetic catalysis. To mimic the active sites of protein phosphatase, Hf-OH-Hf motif-containing metal-organic frameworks (MOFs) were obtained and structurally characterized, which are assembled from [Hf₄₈Ni₆] cubic nanocages and exhibit good stability in various solvents and acid/base solutions. Catalytic investigations suggest as-synthesized Hf-Ni and Hf-Ni-NH ₂ display accurate type-selectivity (selectively catalyzed P-O rather than S-O or C-O bonds) and position-selectivity (selectively catalyzed phosphomonoesters over phosphodiesters) for the hydrolysis of phosphoesters. Reaction kinetic studies further revealed the high activity of the catalytic sites in thes

SUBMITTER: Dong J 

PROVIDER: S-EPMC8161481 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature