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Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond.

ABSTRACT: A highly efficient enantioselective [1,3] O-to-C rearrangement of racemic vinyl ethers that operates under mild conditions was developed. This method with chiral ferrous complex catalyst provided an efficient access to a wide range of chromanols with high yields and excellent enantioselectivities. In addition, an important urological drug (R)-tolterodine and others were easily obtained after simple transformations.

SUBMITTER: Wang L

PROVIDER: S-EPMC8162448 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond.

Wang Lifeng L Zhou Pengfei P Lin Qianchi Q Dong Shunxi S Liu Xiaohua X Feng Xiaoming X

Chemical science 20200907 37

A highly efficient enantioselective [1,3] O-to-C rearrangement of racemic vinyl ethers that operates under mild conditions was developed. This method with chiral ferrous complex catalyst provided an efficient access to a wide range of chromanols with high yields and excellent enantioselectivities. In addition, an important urological drug (<i>R</i>)-tolterodine and others were easily obtained after simple transformations. ...[more]

PMID: 34094271

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