Highly efficient H₂S scavengers via thiolysis of positively-charged NBD amines.

ABSTRACT: H₂S is a well-known toxic gas and also a gaseous signaling molecule involved in many biological processes. Advanced chemical tools that can regulate H₂S levels in vivo are useful for understanding H₂S biology as well as its potential therapeutic effects. To this end, we have developed a series of 7-nitro-1,2,3-benzoxadiazole (NBD) amines as potential H₂S scavengers. The kinetic studies of thiolysis reactions revealed that incorporation of positively-charged groups onto the NBD amines greatly increased the rate of the H₂S-specific thiolysis reaction. We demonstrate that these reactions proceed effectively, with second order rate constants (k ₂) of >116 M^-1 s^-1 at 37 °C for NBD-S8. Ad

SUBMITTER: Ismail I 

PROVIDER: S-EPMC8163142 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature