The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals.

ABSTRACT:

Background

Prior studies in animal models showed that increased cardiac expression of TRIB3 has a pathogenic role in inducing left ventricular mass (LVM). Whether alterations in TRIB3 expression or function have a pathogenic role in inducing LVM increase also in humans is still unsettled. In order to address this issue, we took advantage of a nonsynonymous TRIB3 Q84R polymorphism (rs2295490), a gain-of-function amino acid substitution impairing insulin signalling, and action in primary human endothelial cells which has been associated with insulin resistance, and early vascular atherosclerosis.

Methods

SNP rs2295490 was genotyped in 2426 White adults in whom LVM index (LVMI) was assessed by validated echocardiography-derived measures.

Results

After adjusting for age a

SUBMITTER: Mannino GC 

PROVIDER: S-EPMC8164223 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature