Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections.

ABSTRACT: The increasing prevalence of antimicrobial resistance in pathogens is a growing public health concern, with the potential to compromise the success of infectious disease treatments in the future. Particularly, the number of infections by macrolide antibiotics-resistant Streptococcus pneumoniae is increasing. We show here that Clarithromycin impairs both the frequencies and number of interleukin (IL)-17 producing T helper (Th) 17 cells within the lungs of mice infected with a macrolide-resistant S. pneumoniae serotype 15A strain. Subsequently, the tissue-resident memory CD4⁺ T cell (Trm) response to a consecutive S. pneumoniae infection was impaired. The number of lung resident IL-17⁺ CD69⁺ Trm was diminished upon Clarithromycin treatment during reinfection.

SUBMITTER: Lindenberg M 

PROVIDER: S-EPMC8164591 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature