Ontology highlight
ABSTRACT:
SUBMITTER: Yin Q
PROVIDER: S-EPMC8166076 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Yin Qian Q Yu Wong W Grzeskowiak Caitlin L CL Li Jing J Huang Huang H Guo Jing J Chen Liang L Wang Feng F Zhao Fan F von Boehmer Lotta L Metzner Thomas J TJ Leppert John T JT Chien Yueh-Hsiu YH Kuo Calvin J CJ Kuo Calvin J CJ Davis Mark M MM
Proceedings of the National Academy of Sciences of the United States of America 20210501 21
Tumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens but are generally inactive, although they often show signs of prior clonal expansion. Hypothesizing that this may be due to peripheral tolerance, we formulated nanoparticles containing innate immune stimulants that we found were sufficient to activate self-specific CD8<sup>+</sup> T cells and injected them into two different mouse tumor models, B16F10 and MC38. These nanoparticles robustly activated and/or ...[more]