The influence of low-carbohydrate diets on the metabolic response to androgen-deprivation therapy in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PC) is the second most lethal cancer for men. For metastatic PC, standard first-line treatment is androgen deprivation therapy (ADT). While effective, ADT has many metabolic side effects. Previously, we found in serum metabolome analysis that ADT reduced androsterone sulfate, 3-hydroxybutyric acid, acyl-carnitines but increased serum glucose. Since ADT reduced ketogenesis, we speculate that low-carbohydrate diets (LCD) may reverse many ADT-induced metabolic abnormalities in animals and humans.

Methods

In a multicenter trial of patients with PC initiating ADT randomized to no diet change (control) or LCD, we previously showed that LCD intervention led to significant weight loss, reduced fat mass, improved insulin resistance, and lipid profiles. To

SUBMITTER: Chi JT 

PROVIDER: S-EPMC8167376 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature