Etiology-associated heterogeneity in acute respiratory distress syndrome: a retrospective cohort study.

ABSTRACT:

Background

Heterogeneity in acute respiratory distress syndrome (ARDS) has led to many statistically negative clinical trials. Etiology is considered an important source of pathogenesis heterogeneity in ARDS but previous studies have usually adopted a dichotomous classification, such as pulmonary versus extrapulmonary ARDS, to evaluate it. Etiology-associated heterogeneity in ARDS remains poorly described.

Methods

In this retrospective cohort study, we described etiology-associated heterogeneity in gas exchange abnormality (PaO₂/FiO₂ [P/F] and ventilatory ratios), hemodynamic instability, non-pulmonary organ dysfunction as measured by the Sequential Organ Failure Assessment (SOFA) score, biomarkers of inflammation and coagulation, and 30-day mortality.

SUBMITTER: Ruan SY 

PROVIDER: S-EPMC8168042 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature