Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.

ABSTRACT:

Background

B vitamins have been associated with the risk and progression of colorectal cancer (CRC), given their central roles in nucleotide synthesis and methylation, yet their association with quality of life in established CRC is unclear.

Objectives

To investigate whether quality of life 6 months postdiagnosis is associated with: 1) circulating concentrations of B vitamins and related biomarkers 6 months postdiagnosis; 2) changes in these concentrations between diagnosis and 6 months postdiagnosis; 3) B-vitamin supplement use 6 months postdiagnosis; and 4) changes in B-vitamin supplement use between diagnosis and 6 months postdiagnosis.

Methods

We included 1676 newly diagnosed stage I-III CRC patients from 3 prospective European cohorts. Circulating concentrations

SUBMITTER: Koole JL 

PROVIDER: S-EPMC8168355 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature