Ontology highlight
ABSTRACT:
SUBMITTER: Vavouraki N
PROVIDER: S-EPMC8169945 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Vavouraki Nikoleta N Tomkins James E JE Kara Eleanna E Houlden Henry H Hardy John J Tindall Marcus J MJ Lewis Patrick A PA Manzoni Claudia C
iScience 20210428 5
The Hereditary Spastic Paraplegias are a group of neurodegenerative diseases characterized by spasticity and weakness in the lower body. Owing to the combination of genetic diversity and variable clinical presentation, the Hereditary Spastic Paraplegias are a strong candidate for protein-protein interaction network analysis as a tool to understand disease mechanism(s) and to aid functional stratification of phenotypes. In this study, experimentally validated human data were used to create a prot ...[more]