Synthetic platelet microgels containing fibrin knob B mimetic motifs enhance clotting responses.

ABSTRACT: Native platelets are crucial players in wound healing. Key to their role is the ability of their surface receptor GPIIb/IIIa to bind fibrin at injury sites, thereby promoting clotting. When platelet activity is impaired as a result of traumatic injury or certain diseases, uncontrolled bleeding can result. To aid clotting and tissue repair in cases of poor platelet activity, our lab has previously developed synthetic platelet-like particles capable of promoting clotting and improving wound healing responses. These are constructed by functionalizing highly deformable hydrogel microparticles (microgels) with fibrin-binding ligands including a fibrin-specific whole antibody or a single-domain variable fragment. To improve the translational potential of these clotting materials, we explored the

SUBMITTER: Nandi S 

PROVIDER: S-EPMC8171167 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature