Inverse association between hypertension treatment and COVID-19 prevalence in Japan.

ABSTRACT:

Objectives

Cell entry of SARS-CoV-2 depends on angiotensin-converting enzyme II. Angiotensin-converting enzyme II is homologous with, but acts antagonistically to, angiotensin-converting enzyme and has the critical function of protecting the lungs. Angiotensin-converting enzyme inhibitors are major antihypertensive agents. Thus, we aimed to analyze the impact of the prevalence of preexisting hypertension on the local spread of COVID-19.

Methods

Data on SARS-CoV-2 infection and the estimated number of patients who received medical treatment on the basis of disease classification using the International Statistical Classification of Diseases and Related Health Problems (10th Revision) in each prefecture were obtained from the official Japanese notifications database. We analyz

SUBMITTER: Kinoshita M 

PROVIDER: S-EPMC8172356 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature