Carbon-Source Dependent Interplay of Copper and Manganese Ions Modulates the Morphology and Itaconic Acid Production in Aspergillus terreus.

ABSTRACT: The effects of the interplay of copper(II) and manganese(II) ions on growth, morphology and itaconic acid formation was investigated in a high-producing strain of Aspergillus terreus (NRRL1960), using carbon sources metabolized either mainly via glycolysis (D-glucose, D-fructose) or primarily via the pentose phosphate shunt (D-xylose, L-arabinose). Limiting Mn²⁺ concentration in the culture broth is indispensable to obtain high itaconic acid yields, while in the presence of higher Mn²⁺ concentrations yield decreases and biomass formation is favored. However, this low yield in the presence of high Mn²⁺ ion concentrations can be mitigated by increasing the Cu²⁺ concentration in the medium when D-glucose or D-fructose is the growth substrate,

SUBMITTER: Sandor E 

PROVIDER: S-EPMC8173074 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature