Expression of p16 and p53 in non-small-cell lung cancer: clinicopathological correlation and potential prognostic impact.
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ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC8173521 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Expression of p16 and p53 in non-small-cell lung cancer: clinicopathological correlation and potential prognostic impact.
Zhou Yangying Y Höti Naseruddin N Ao Minghui M Zhang Zhen Z Zhu Hong H Li Ling L Askin Frederic F Gabrielson Edward E Zhang Hui H Li Qing Kay QK
Biomarkers in medicine 20190603 9
<b>Aim:</b> p16 and p53 are frequently altered intracellular pathways in cancers. We investigated the aberrant expression of p16 and its relationship with p53 and HPV status in primary non-small-cell lung carcinoma. <b>Patients & methods:</b> Lung tumor tissue microarray (n = 163), immunohistochemical study of p16 and p53, and HPV <i>in-situ</i> hybridization were analyzed. <b>Results:</b> p16 and p53 were detected in 50.7 and 57.3% of adenocarcinoma (ADCs; n = 75), and 35.2 and 63.6% of squamou ...[more]
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