Unknown

Dataset Information

0

Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.

ABSTRACT: Epithelial-mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete picture of this biological process is yet to be elucidated. To comprehensively profile EMT-related genes in colorectal cancer, we quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it "mesenchymal score." This bioinformatic approach successfully identified 90 candidate EMT mediators, which are strongly predictive of survival in clinical samples. Among these candidates, we discovered that the neuronal gene ARC, possibly originating from the retrotransposon, unexpectedly plays a crucial role in EMT induction. Profiling of novel EMT mediators we demonstrated here may help understand the complexity of the EMT program and open up new avenues for therapeutic intervention in colorectal cancer.

SUBMITTER: Ishikawa S 

PROVIDER: S-EPMC8175715 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.

Ishikawa Satoshi S   Nishida Naohiro N   Fujino Shiki S   Ogino Takayuki T   Takahashi Hidekazu H   Miyoshi Norikatsu N   Uemura Mamoru M   Satoh Taroh T   Yamamoto Hirofumi H   Mizushima Tsunekazu T   Doki Yuichiro Y   Eguchi Hidetoshi H  

Scientific reports 20210603 1

Epithelial-mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete picture of this biological process is yet to be elucidated. To comprehensively profile EMT-related genes in colorectal cancer, we quantified the EMT induction ability of each gene according to its similar  ...[more]

Similar Datasets

Unknown A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition.
| S-EPMC3110206 | biostudies-literature
Unknown Clinical Significance of Circulating Tumor Cell Induced Epithelial-Mesenchymal Transition in Patients with Metastatic Colorectal Cancer by Single-Cell RNA-Sequencing.
| S-EPMC8507666 | biostudies-literature
Unknown Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: comprehensive immunohistochemical study using a tissue microarray.
| S-EPMC4183847 | biostudies-other
Unknown Clinical significance of <i>Fusobacterium nucleatum</i>, epithelial-mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients.
| S-EPMC5652912 | biostudies-literature
Unknown Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance.
| S-EPMC5494835 | biostudies-other
Unknown A novel epithelial-mesenchymal transition molecular signature predicts the oncological outcomes in colorectal cancer.
| S-EPMC8034457 | biostudies-literature
Unknown Clinical Significance of Combined Epithelial-Mesenchymal Transition Markers Expression and Role of Rac1 in Hepatocellular Carcinoma.
| S-EPMC9865966 | biostudies-literature
Unknown Morphological single cell profiling of the epithelial-mesenchymal transition.
| S-EPMC5417362 | biostudies-literature
Unknown Reliable epithelial-mesenchymal transition biomarkers for colorectal cancer detection.
| S-EPMC9442548 | biostudies-literature
Unknown Portal Venous Circulating Tumor Cells Undergoing Epithelial-Mesenchymal Transition Exhibit Distinct Clinical Significance in Pancreatic Ductal Adenocarcinoma.
| S-EPMC8582019 | biostudies-literature