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Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.

ABSTRACT: During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC₅₀ values of 3.8 and 12.8 nM, respectively.

SUBMITTER: Otsuki K

PROVIDER: S-EPMC8176626 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.

Otsuki Kouharu K Zhang Mi M Yamamoto Asuka A Tsuji Minami M Tejima Miyuko M Bai Zi-Song ZS Zhou Di D Huang Li L Chen Chin-Ho CH Lee Kuo-Hsiung KH Li Ning N Li Wei W Koike Kazuo K

Journal of natural products 20201110 12

During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 ce ...[more]

PMID: 33172265

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