Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.

ABSTRACT:

Background

Short-duration exposure to ambient particulate matter (PM) air pollution is associated with cardiac autonomic dysfunction and prolonged ventricular repolarization. However, associations with sub-chronic exposures to coarser particulates are relatively poorly characterized as are molecular mechanisms underlying their potential relationships with cardiovascular disease.

Materials and methods

We estimated associations between monthly mean concentrations of PM < 10 μm and 2.5-10 μm in diameter (PM_10; PM_2.5-10) with time-domain measures of heart rate variability (HRV) and QT interval duration (QT) among U.S. women and men in the Women's Health Initiative and Atherosclerosis Risk in Communities Study (n_HRV = 82,107; n_QT = 76,7

SUBMITTER: Gondalia R 

PROVIDER: S-EPMC8179344 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature