Differential analysis revealing APOC1 to be a diagnostic and prognostic marker for liver metastases of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most malignant gastrointestinal cancers worldwide. The liver is the most important metastatic target organ, and liver metastasis is the leading cause of death in patients with CRC. Owing to the lack of sensitive biomarkers and unclear molecular mechanism, the occurrence of liver metastases cannot be predicted and the clinical outcomes are bad for liver metastases. Therefore, it is very important to identify the diagnostic or prognostic markers for liver metastases of CRC.

Aim

To investigate the highly differentially expressed genes (HDEGs) and prognostic marker for liver metastases of CRC.

Methods

Data from three NCBI Gene Expression Omnibus (GEO) datasets were used to show HDEGs between liver metastases of CRC and tumo

SUBMITTER: Shen HY 

PROVIDER: S-EPMC8180235 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature