Dataset Information

Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.

ABSTRACT: Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = -0.111 to -0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.

SUBMITTER: Wang X

PROVIDER: S-EPMC8180531 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.

Wang Xin X Xie Hong H Chen Tian T Cotton Andrew S AS Salminen Lauren E LE Logue Mark W MW Clarke-Rubright Emily K EK Wall John J Dennis Emily L EL O'Leary Brian M BM Abdallah Chadi G CG Andrew Elpiniki E Baugh Lee A LA Bomyea Jessica J Bruce Steven E SE Bryant Richard R Choi Kyle K Daniels Judith K JK Davenport Nicholas D ND Davidson Richard J RJ DeBellis Michael M deRoon-Cassini Terri T Disner Seth G SG Fani Negar N Fercho Kelene A KA Fitzgerald Jacklynn J Forster Gina L GL Frijling Jessie L JL Geuze Elbert E Gomaa Hassaan H Gordon Evan M EM Grupe Dan D Harpaz-Rotem Ilan I Haswell Courtney C CC Herzog Julia I JI Hofmann David D Hollifield Michael M Hosseini Bobak B Hudson Anna R AR Ipser Jonathan J Jahanshad Neda N Jovanovic Tanja T Kaufman Milissa L ML King Anthony P AP Koch Saskia B J SBJ Koerte Inga K IK Korgaonkar Mayuresh S MS Krystal John H JH Larson Christine C Lebois Lauren A M LAM Levy Ifat I Li Gen G Magnotta Vincent A VA Manthey Antje A May Geoffrey G McLaughlin Katie A KA Mueller Sven C SC Nawijn Laura L Nelson Steven M SM Neria Yuval Y Nitschke Jack B JB Olff Miranda M Olson Elizabeth A EA Peverill Matthew M Phan K Luan KL Rashid Faisal M FM Ressler Kerry K Rosso Isabelle M IM Sambrook Kelly K Schmahl Christian C Shenton Martha E ME Sierk Anika A Simons Jeffrey S JS Simons Raluca M RM Sponheim Scott R SR Stein Murray B MB Stein Dan J DJ Stevens Jennifer S JS Straube Thomas T Suarez-Jimenez Benjamin B Tamburrino Marijo M Thomopoulos Sophia I SI van der Wee Nic J A NJA van der Werff Steven J A SJA van Erp Theo G M TGM van Rooij Sanne J H SJH van Zuiden Mirjam M Varkevisser Tim T Veltman Dick J DJ Vermeiren Robert R J M RRJM Walter Henrik H Wang Li L Zhu Ye Y Zhu Xi X Thompson Paul M PM Morey Rajendra A RA Liberzon Israel I

Molecular psychiatry 20201207 8

Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can ...[more]

PMID: 33288872

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Project description:BackgroundRecent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, and different imaging collection protocols, limit the ability to directly compare and generalize their results. Here we aimed to classify individuals with PTSD versus controls and assess the generalizability using a large heterogeneous brain datasets from the ENIGMA-PGC PTSD Working group.MethodsWe analyzed brain MRI data from 3,477 structural-MRI; 2,495 resting state-fMRI; and 1,952 diffusion-MRI. First, we identified the brain features that best distinguish individuals with PTSD from controls using traditional machine learning methods. Second, we assessed the utility of the denoising variational autoencoder (DVAE) and evaluated its classification performance. Third, we assessed the generalizability and reproducibility of both models using leave-one-site-out cross-validation procedure for each modality.ResultsWe found lower performance in classifying PTSD vs. controls with data from over 20 sites (60 % test AUC for s-MRI, 59 % for rs-fMRI and 56 % for d-MRI), as compared to other studies run on single-site data. The performance increased when classifying PTSD from HC without trauma history in each modality (75 % AUC). The classification performance remained intact when applying the DVAE framework, which reduced the number of features. Finally, we found that the DVAE framework achieved better generalization to unseen datasets compared with the traditional machine learning frameworks, albeit performance was slightly above chance.ConclusionThese results have the potential to provide a baseline classification performance for PTSD when using large scale neuroimaging datasets. Our findings show that the control group used can heavily affect classification performance. The DVAE framework provided better generalizability for the multi-site data. This may be more significant in clinical practice since the neuroimaging-based diagnostic DVAE classification models are much less site-specific, rendering them more generalizable.

Project description:Alcohol use disorder (AUD) and cannabis use disorder (CUD) are associated with brain alterations particularly involving fronto-cerebellar and meso-cortico-limbic circuitry. However, such abnormalities have additionally been reported in other psychiatric conditions, and until recently there has been few large-scale investigations to compare such findings. The current study uses the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium method of standardising structural brain measures to quantify case-control differences and to compare brain-correlates of substance use disorders with those published in relation to other psychiatric disorders. Using the ENIGMA protocols, we report effect sizes derived from a meta-analysis of alcohol (seven studies, N = 798, 54% are cases) and cannabis (seven studies, N = 447, 45% are cases) dependent cases and age- and sex-matched controls. We conduct linear analyses using harmonised methods to process and parcellate brain data identical to those reported in the literature for ENIGMA case-control studies of major depression disorder (MDD), schizophrenia (SCZ) and bipolar disorder so that effect sizes are optimally comparable across disorders. R elationships between substance use disorder diagnosis and subcortical grey matter volumes and cortical thickness were assessed with intracranial volume, age and sex as co-variates . After correcting for multiple comparisons, AUD case-control meta-analysis of subcortical regions indicated significant differences in the thalamus, hippocampus, amygdala and accumbens, with effect sizes (0.23) generally equivalent to, or larger than |0.23| those previously reported for other psychiatric disorders (except for the pallidum and putamen). On measures of cortical thickness, AUD was associated with significant differences bilaterally in the fusiform gyrus, inferior temporal gyrus, temporal pole, superior frontal gyrus, and rostral and caudal anterior cingulate gyri. Meta-analysis of CUD case-control studies indicated reliable reductions in amygdala, accumbens and hippocampus volumes, with the former effect size comparable to, and the latter effect size around half of that reported for alcohol and SCZ. CUD was associated with lower cortical thickness in the frontal regions, particularly the medial orbitofrontal region, but this effect was not significant after correcting for multiple testing. This study allowed for an unbiased cross-disorder comparison of brain correlates of substance use disorders and showed alcohol-related brain anomalies equivalent in effect size to that found in SCZ in several subcortical and cortical regions and significantly greater alterations than those found in MDD in several subcortical and cortical regions. Although modest, CUD results overlapped with findings reported for AUD and other psychiatric conditions, but appear to be most robustly related to reduce thickness of the medial orbitofrontal cortex.

Dataset Information

Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.

Publications

Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.

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